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Beilstein J. Org. Chem. 2010, 6, No. 71, doi:10.3762/bjoc.6.71
Graphical Abstract
Figure 1: Design of a new DPP-4 inhibitor (C) based on Alogliptin (A) and other inhibitors (B).
Figure 2: Strategy to prepare compound C (PG = protecting group).
Scheme 1: Reagents and conditions: (i) EtONa, BrCH2CH2Br, EtOH, reflux, 3.5 h (70% yield); (ii) Pd/C, MeOH, H2...
Scheme 2: Reagents and conditions: (i) NaH, LiBr, DMF - DMSO, 12 h (55% yield); (ii) NaH, LiBr, CH3I, DMF - T...
Figure 3: Predicted interactions of compound C with DPP-4.